Re2O Skin Booster: How Is It Performed, and How Often Should You Get It?

Re2O is typically received 2–3 sessions or more at intervals of 3–4 weeks (about 1 month), followed by maintenance treatments every 6–12 months depending on your skin condition.
Re2O is an injection that replenishes the dermis with extracellular matrix (ECM) derived from donated human dermis. Rather than delivering a set result in a single session, it is a treatment in which the condition of the dermis changes gradually over successive sessions, so planning the intervals and number of sessions from the start makes scheduling easier.
What Re2O Replenishes
It is made from acellular human dermal matrix (hADM), from which cellular components that may trigger immune responses have been removed, processed into injectable particles. The ingredients delivered to the dermis can be divided into three groups.
- Fibrous components: Contains collagen and elastin—components that shape the skin and support its elasticity.
- Ground substance: Hyaluronic acid, proteoglycans, and fibronectin are included together. They fill the spaces between fibers and help form the dermal structure.
- Replenishing approach: Its starting point differs from injections that stimulate new collagen production. It replenishes the structure by delivering the very components that make up the dermis.
Learn what it means that Re2O replenishes the extracellular matrix
Treatment steps at our Suwon clinic
- Consultation: We first assess your skin condition, dermal thickness, and the areas to be treated.
- Topical anesthesia: An anesthetic is applied to the treatment area to reduce discomfort.
- Injection: The ECM ingredients are evenly injected into the dermis.
- Soothing and guidance: After soothing care, we explain how to moisturize and protect your skin from the sun.
It takes approximately 1 hour, including anesthesia time. The amount is chosen based on the facial area and skin thickness.
What Happens in Your Skin Between Sessions
With an interval of 3–4 weeks, the period when swelling subsides and the period when skin texture begins to change pass in turn before the next session.
| Period | Skin condition | What to do |
|---|---|---|
| On the day of treatment | Temporary swelling or tightness may occur at injection sites | Begin moisturizing and sun protection |
| 2–7 days | Mild swelling and tightness usually subside | Avoid saunas, strenuous exercise, and alcohol |
| 1 to 2 weeks | Changes in skin texture and elasticity appear gradually | Keep moisturizing and observe the changes |
| 3–4 weeks | Time for your next session | Book on the date you were advised |
Recommended intervals and number of sessions by stage
1. Initial intensive sessions
- Recommended interval: 3–4 weeks, approximately 1 month apart
- Recommended number: 2–3 sessions or more
- Characteristics: Each session replenishes the dermal structure, and additional sessions are added based on the degree of aging and skin condition.
2. Maintenance treatment after the intensive sessions
- Recommended interval: 6–12 months depending on skin condition
- Characteristics: The timing of the next session is chosen based on the changes in skin texture and elasticity during the intensive sessions.
3. When planned together with lifting
- Recommended device: ALLTITE Lifting
- Characteristics: A combination for those who want both skin recovery and texture refinement after lifting or laser treatments.
Who this treatment suits
- Those who feel their skin has become thinner and less firm with age
- Those concerned about dry, dull skin texture
- Those concerned about fine lines, pores, and reduced skin density all at once
- Those who prefer directly replenishing dermal components over stimulating collagen production
Precautions on the Day of Treatment (The Most Important 24 Hours)
- Do not rub or press hard on the injected areas.
- Do not force massage even if you feel swelling or tightness.
- Apply the recommended moisturizer, and use sunscreen when going outdoors.
What to Avoid for One Week
- Saunas, jjimjilbang (Korean bathhouses), and strenuous exercise
- Alcohol and smoking
Post-Treatment Care
- Continue moisturizing and sun protection consistently until your next session.
- Depending on skin condition, redness, bruising, or small bumps may appear, and these usually diminish within 2–7 days. Please contact us right away if swelling or redness worsens day by day, if warmth or pain increases, or if your skin color changes from usual.
- As this product is made from human-derived tissue, please inform us before treatment if you have a history of allergies. Please also let us know in advance if you are pregnant or breastfeeding, or if there is any infection or inflammation in the treatment area.
Booking and consultation
Face Filter Clinic Suwon offers Re2O as 5cc in 1 or 2 sessions, and as a package using 3 syringes for the full face and neck with added neck Skin Botox. A combination with ALLTITE Lifting is also available, and during a personalized consultation we assess dermal thickness and treatment areas to determine the dosage and number of sessions.
This content is provided as general treatment information and is not a substitute for diagnosis or treatment. Always consult a medical professional to decide whether and how to proceed with a treatment.